association between serum biochemical levels, related to bone metabolism and parkinson’s disease

normal 0 false false false en-us x-none ar-sa background: vitamin d insufficiency and serum calcium disturbance have been reported to be more common in parkinson’s disease (pd) patients than in healthy control subjects, which may be due to a chronic disease or reduced mobility contributes to these relatively disturbances. because of the high-vitamin d insufficiency in our population, we aimed to compare a biochemical levels which are related to bone metabolism, in pd patients in comparison with age-matched healthy controls, for the 1 st time in a middle east population. materials and methods: this case-control study was involved 105 (20 were excluded) pd patients, who were age- and -sex matched with 112 controls. 25-hydroxyvitamin d ( 25ohd) and parathyroid hormone analyzed by enzyme immunoassay; another laboratory data including, calcium, phosphorous, and alkaline phosphatase were performed by spectrophotometric methods. results: there was no significant difference in 25ohd between pd patients and control group ( p = 0.071). 25ohd level was not significantly different in pd patients compared to controls {odds ratio 1.003, ( c onfidence interval [ci], 0.98-1.02), p value 0.793}. none of the other biochemical levels did not induce more chance for pd, only we observed in men has more risk of pd than women (odds ratio 2.53, [ci, 1.27-5.03], p value 0.008). conclusion: our data do not support a possible role of vitamin d insufficiency in pd. regarding to variable changes in biochemical markers in pd patients than in controls; further studies are suggested to determine any plausibility role of them as a causal relationship or as an outcome of pd.